LABORATORY ANALISYS AND TESTING TEHNIQUE SERVICES

Authorization according to Good Manufacturing Practice rules.

ISO 9001 Certification

1. Physical, physico-chemical and chemical methods1.1. Physical methods

Refraction index
Boiling point
Melting point
Drip point
Point of solidification
Viscosity
Relative density
Rotating power
Determination of alcohol concentration
Determination of the conductivity
Electrophoresis
tonicity

1.2. Physico-chemical methods

Solubility
The appearance and coloring of the solutions
Loss through drying
Residue by calcination
Determination of pH
Determination of water
Potentiometric titration
Content of total organic carbon
Determination of phenol content

1.3. Chemical methods

indices:

Acidity index
Ester index
Hydroxyl index
Peroxide index
Saponification index
Substances that are not asconifiable
Control of limits for inorganic impurities
Nitrogen dosage from organic combinations

2. Instrumental methods

2.1. Spectrophotometry

Ultraviolet and visible spectrophotometry
Infrared spectrophotometry
Atomic absorption spectrophotometry
Inductive coupled plasma optical emission spectrometry ICP-OES

2.2. chromatography

Thin layer chromatography
Gas chromatography
Chromatography of liquid under pressure

3. Pharmacotechnical methods

disintegration
Dissolution
Determination of particle size of powders
Determination of sub-visible particles
Determination of visible particles

4. Pharmacognostic methods

Dosage of soluble substances in plant products
Dosing of tannins from vegetable products
Dosage of volatile oils from vegetable products
Polyholoside dosage from plant products
Carotene and fat-soluble vitamins dosage from plant products
Dosage of fatty acids from vegetable products
Determination of the degree of contamination of plant products with residues of organo-chlorinated and organo-phosphoric pesticides

5. Biological and microbiological methods

Sterility control
Microbial contamination
Monitoring the effectiveness of preservatives
Microbiological activity of antibiotics
Pyrogenic impurities (outsourcing)
Toxic impurities
Determination of bacterial endotoxins
Determination of sodium heparin
antigen
Testing the mutagenic potential, by highlighting the phenotypes determined by reverse gene mutations in bacteria (Ames test).

6. Testing the stability of the drug

Long-term conditions
Accelerated conditions
photostability

7. Development and validation of control methodology.

8. Validation and analytical transfer

RESEARCH SERVICES

According to Good Clinical Practice Rules

ISO 9001 Certification

1. Skin tolerance studies for cosmetics:

the irritating potential,
the sensitizing potential,
allergic potential,

2. Efficiency studies for cosmetic products:

identification of the product effect
demonstration of the declared effect
moisturizing effect
regenerative effect
antiaging effect, including restoration of dermal structural proteins (eg collagen)
anti-edematous effect
anti-cellulite effect
anti-acne effect

3. Non-invasive instrumental methods:

Cutometer®

SEBUMETRIE

MEXAMETRY: – determination of erythema, melanin determination.

CUTOMETRY – DETERMINATION OF ELASTICITY OF SKIN

SELS (Surface Evaluation of the Living Skin) ASSESSMENT OF THE SURFACE PARAMETERS OF THE SKIN:

“Skin smoothness” (SEsm) – skin dryness

“Skin roughness” (SEr) – the roughness of the skin

“Scaliness” (SEsc) – indicates the degree of decomposition of the horny layer

“Wrinkles” (SEw) – skin wrinkles

DETERMINATION OF TRANSPARMAL WATER EVAPORATION

DETERMINING THE pH OF THE SKIN

ULTRASONOGRAPHIC ASSESSMENTS WITH DERMASCAN C in skin and joint tissue – with multiple applications

Degradation / restoration of joint collagen

Collagen fibers from the dermal matrix as a result of photo-aging, as well as the reversibility of the process in the case of an effective treatment

Measurement of subcutaneous tissue thickness

Measurement of the thickness of the epidermis, dermis

Analysis of allergic and irritant reactions by visualizing edema and inflammatory infiltrates (measuring the dimensions of hyporeflective areas)

Skin reactivity to allergens (eg applications for patch tests)

Cutaneous atrophy after drug treatment (eg corticosteroids)